Expert Scientific Services
Six specialized service areas designed for seed- and Series A-stage biotechs advancing gene therapy and gene editing programs toward the clinic.
All Services
Functional Genomics Strategy
End-to-end design and execution of genome-wide and targeted CRISPR screens. Services include sgRNA library selection and synthesis, viral transduction or electroporation optimization, pooled screen execution, NGS-based library deconvolution, and MAGeCK/BAGEL2 analysis. Applicable in cancer models, primary HSCs, iPSC-derived cell types, and organoid systems.
Translational Biology Support
Scientific leadership across the IND-enabling spectrum — from disease biology assessment and proof-of-concept study design to CRO selection and management, protocol development, and data interpretation. Specialized expertise in gene therapy, base editing, and prime editing programs in hematopoietic stem cells and liver-targeted therapeutics.
Biomarker Development Strategy
Identification, selection, and analytical strategy for protein and genetic biomarkers in gene therapy clinical programs. Services include context-of-use definition, biomarker qualification roadmap development, and analytical framework for Phase 1 trial design. Expertise in pharmacodynamic biomarkers, patient stratification markers, and safety biomarkers specific to gene editing modalities.
Assay Development & Qualification
Full lifecycle assay development from exploratory research to GLP-aligned validation. Specialized in ddPCR editing efficiency assays, NGS-based off-target detection panels, CRISPR screen readout qualification, and multiplex biomarker panels. All deliverables include SOPs, analytical validation reports, and raw data packages suitable for IND filing.
AI/ML Applications in Biology
Large-scale Perturb-seq dataset generation specifically designed for training gene expression foundation models and AI-driven drug target discovery platforms. Services include experimental design for perturbation coverage, cell line engineering, sgRNA library construction, 10x Genomics Chromium single-cell RNA-seq execution, preliminary QC and analysis, and structured data delivery in AI/ML-compatible formats.
Gene Therapy Research Support
Specialized support for gene therapy and gene editing programs advancing through preclinical and IND-enabling stages. Includes CRISPR/Cas9 and base editing target validation, CD34+ hematopoietic stem cell engineering and culture optimization, electroporation and RNP delivery protocols, and integration with FDA pre-IND guidance and regulatory pathway strategy.
Three Service Tiers
Structured, fixed-price packages with milestone-based billing. All tiers include GLP-aligned documentation and a dedicated scientific point of contact.
| Tier | Scope & Deliverables | Duration | Investment |
|---|---|---|---|
| Tier 1 — Technical Audit & Strategy Ideal for seed-stage biotechs with a scientific question needing direction | Written strategy memo (15–25 pp), assay feasibility scorecard, CRO/vendor benchmarking, regulatory pathway brief. Delivered as PDF + live readout call. | 2–4 weeks | $8,000 – $15,000 |
| Tier 2 — Assay Design & Validation Ideal for companies preparing IND submissions requiring qualified biomarker assays | Full assay development package: SOPs, analytical method report, validation data, reagent guide, transfer protocols. Milestone billing: 30% / 40% / 30%. | 2–5 months | $40,000 – $120,000 |
| Tier 3 — Full Translational Roadmap Fractional Chief Translational Officer for seed / pre-Series A biotechs | Complete IND-enabling translational package: target validation data, biomarker development, Phase 1 trial design input, CRO management, FDA pre-IND preparation, investor data room. Monthly retainer basis. | 6–18 months | $15K–$30K/month |
All engagements begin with a complimentary 30-minute discovery call. Schedule yours →
What's Always Included
Let's discuss your program.
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